Chloral hydrate
Chloral hydrate
CAS: 302-17-0
Molecular Formula: C2H3Cl3O2
Chloral hydrate - Names and Identifiers
| Name | Chloral hydrate |
| Synonyms | Escre sontec somnos nycton Noctec nortec dormal lorinal nycoton bi 3411 trawotox felsules rectules somni sed phaldrone kessodrate aquachloral chloraldurat 'SCHLIFF-AUF' Chloral hydrate sk-chloral hydrate trichloroacetaldehyde hydrate TRICHLOROACETALDEHYDE HYDRATE CHLORAL HYDRATE, CRYSTALLIZED 1,1,1-trichloro-2,2-ethanediol 2,2,2-trichloroethane-1,1-diol 2,2,2-TRICHLOROETHANE-1,1-DIOL 2,2,2-Trichloro-1,1-ethanediol TRICHLOROACETALDEHYDE MONOHYDRATE Trichloroacetaldehyde Monohydrate 2,2,2-TRICHLOROETHANE-1,1-DIOL HYDRATE |
| CAS | 302-17-0 |
| EINECS | 206-117-5 |
| InChI | InChI=1/C2HCl3O.H2O/c3-2(4,5)1-6;/h1H;1H2 |
| InChIKey | RNFNDJAIBTYOQL-UHFFFAOYSA-N |
Chloral hydrate - Physico-chemical Properties
| Molecular Formula | C2H3Cl3O2 |
| Molar Mass | 165.4 |
| Density | 1.43g/mLat 20°C |
| Melting Point | 57°C(lit.) |
| Boling Point | 97 °C |
| Flash Point | 16°C |
| Water Solubility | 660 g/100 mL |
| Solubility | Very soluble in water, freely soluble in ethanol (96 per cent). |
| Vapor Presure | 19.998hPa at 25℃ |
| Specific Gravity | 1.91 |
| Merck | 13,2080 |
| BRN | 1698497 |
| pKa | 10(at 25℃) |
| PH | 3.5-5.5 (20℃, 10%) |
| Storage Condition | 0-6°C |
| Stability | Stable, but may be air or light sensitive. Incompatible with alcohols, cyanides, iodine, strong bases, carbonates. |
| Refractive Index | 1.4603 (estimate) |
| Physical and Chemical Properties | Density 1.908 melting point 57°C boiling point 97°C water solubility 660g/100 mL |
| Use | Used as pesticides, pharmaceutical intermediates, also used in the preparation of chloroform, trichloroacetaldehyde |
Chloral hydrate - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R36/38 - Irritating to eyes and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S25 - Avoid contact with eyes. S23 - Do not breathe vapour. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S27 - Take off immediately all contaminated clothing. |
| UN IDs | UN 3286 3/PG 2 |
| WGK Germany | 2 |
| RTECS | FM8750000 |
| HS Code | 29055900 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 479mg/kg |
Chloral hydrate - Upstream Downstream Industry
| Raw Materials | Chlorine Chloral Chloral Ethyl Alcohol |
| Downstream Products | Trichloroacetic acid |
Chloral hydrate - Standard
Authoritative Data Verified Data
This product is 2,2, 2-trichloro-1, 1-ethanediol. The content of C2H3C1302 shall not be less than 99.0%.
Last Update：2024-01-02 23:10:35
Chloral hydrate - Trait
Authoritative Data Verified Data
- This product is white or colorless transparent crystal; Irritant special odor; Gradually volatilize in the air.
- This product is easily soluble in water and soluble in ethanol, chloroform or ether.
Last Update：2022-01-01 11:33:45
Chloral hydrate - Differential diagnosis
Authoritative Data Verified Data
take 0.2g of this product, add 2ml of water to dissolve, add 2ml of sodium hydroxide test solution, the solution is turbid; After warming, the two liquid layers are clear, and the odor of chloroform occurs.
Last Update：2022-01-01 11:33:46
Chloral hydrate - Exam
Authoritative Data Verified Data
acidity
take l.Og of this product, Add 10ml of water to dissolve, and measure it according to law (General rule 0631). The pH value should be 0~6.0.
chloride
take 0.50g of this product and check it according to law (General rule 0801). Compared with the control solution made of 0.010% of standard sodium chloride solution, it should not be more concentrated ().
triacetaldehyde alcohol
take l.Og of this product, add 4ml of water and 2ml of sodium hydroxide test solution, shake well, filter, add iodine test solution to the filtrate to be dark brown, and place it for 1 hour, and no yellow crystalline precipitate should be generated.
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 11:33:46
Chloral hydrate - Content determination
Authoritative Data Verified Data
take about 4g of this product, precision weigh, add 10ml of water to dissolve, precision add sodium hydroxide titration solution (lmol/L)30rnl, shake, stand for 2 minutes, add several drops of phenolphthalein indicator solution, titration with sulfuric acid titration solution (0.5mol/L) until the red color disappears, add 6 drops of potassium chromate indicator solution, and use silver nitrate titration solution (0.1 mol/L) titration; The volume (ml) of the consumption sulfuric acid titration solution (0.5mol/L) is subtracted from the volume (ml) of the sodium hydroxide titration solution (1 mol/L), then subtract the consumption of silver nitrate titration solution (0.lmol/L) volume (ml) of 2/15. Each 1 ml of sodium hydroxide titration solution (1 mol/U corresponds to 165.4mg of C2H3C1302.
Last Update：2022-01-01 11:33:47
Chloral hydrate - Category
Authoritative Data Verified Data
hypnotic drugs, anticonvulsants.
Last Update：2022-01-01 11:33:47
Chloral hydrate - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:33:47
Chloral hydrate - Reference Information
| LogP | 1.092 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 2A (vol. 63, 84, 106) 2014 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | hypnotics. Intermediate of DDT. used as pesticides, pharmaceutical intermediates, also used in the preparation of chloroform, chloroacetaldehyde, etc. zinc plating brightener, grain refiner used in the preparation of DDT for medicine verification and determination of silver. Organic synthesis, manufacturing trichloroacetic acid, DDT, etc. Nickel plating brightener It is used as an intermediate for nickel plating, as well as an intermediate for medicine and pesticides, and as an intermediate for making trichlorfon, herbicides and other pesticides. Used as a semi-bright nickel brightener to adjust the potential difference between bright nickel and semi-bright nickel. Chloral hydrate can be used as a hypnotic and anticonvulsant for insomnia, irritability and convulsions. |
| production method | stirring trichloroacetaldehyde, hydroquinone, sodium carbonate and calcium carbonate together and heating to 90 ℃. Distillate under reduced pressure to collect 30 ℃(5.32-10.64kPa) fractions to obtain refined chloroacetaldehyde. Under stirring, slowly add 0.182 times the amount of water until the reaction liquid is porridge-like and let it stand and crystallize. Filtration, low temperature drying, chloral hydrate. |
| category | flammable substances |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 479 mg/kg; Oral-mouse LD50: 1100 mg/ |
| flammability hazard characteristics | when heated, open flame burns; thermal decomposition emits toxic chloride smoke |
| storage and transportation characteristics | warehouse low temperature ventilation and drying; Anti-open flame, high temperature, separate from food raw materials and oxidant |
| fire extinguishing agent | carbon dioxide, foam, dry powder |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:49
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Raw Materials for Chloral hydrate
Downstream Products for Chloral hydrate